As a Senior Research Scientist you will be joining the world’s largest & most comprehensive clinical research organisation, powered by healthcare intelligence.

We are seeking a scientist to support cancer drug discovery programs through in vitro target validation studies. The role involves working independently with molecular and cellular biology techniques, including genetic screens (CRISPR/shRNA), and applying knowledge of cancer biology. Experience with myeloid diseases (AML, MDS, MPN), oncogenic signaling pathways, and targeted therapies is a plus. The scientist will collaborate with their supervisor to design and execute experiments that answer key questions about target biology.

What you will be doing:

• Quantify gene and protein expression in cell lines and patient samples
• Design reagents necessary for genetic screens and validation of knock-down
• Execute and interpret cell-based assays to evaluate the impact of target knockdown or inhibition.
• Ability to maintain accurate and detailed records of experiments, evaluate data, prepare reports and presentations for internal meetings in a timely manner.
• Should be proficient at reviewing the relevant scientific literature to build protocols using Pubmed and other resources.
• Collaborate with other functional groups within drug discovery to achieve shared goals.
• Flexibility to acquire additional competencies and skillsets as needed.
• Should be highly independent and organized, with excellent verbal and written communication skills.

You are:

• Master's degree with 2+ years experience or PhD with 0-2 years experience in Molecular/Cell Biology or related fields.
• Strong in vitro skills including cancer cell-based experiments with CRISPR/shRNA, therapeutics, and tool compounds
• Proficient in molecular biology techniques, including Western Blotting, ddPCR, multicolor flow cytometry, ELISA, HTRF, MSD, and CTG.
• Desirable but not required: experience in ex-vivo culture of human cells, immune cell separation using magnetic beads.
• Experience in myeloid disease biology (AML, MDS, MPN) preferred
• Office based in Wilmington. DE

What ICON can offer you:

Our success depends on the quality of our people. That’s why we’ve made it a priority to build a diverse culture that rewards high performance and nurtures talent.

In addition to your competitive salary, ICON offers a range of additional benefits. Our benefits are designed to be competitive within each country and are focused on well-being and work life balance opportunities for you and your family.

Our benefits examples include:

• Various annual leave entitlements
• A range of health insurance offerings to suit you and your family’s needs
• Competitive retirement planning offerings to maximise savings and plan with confidence for the years ahead
• Global Employee Assistance Programme, TELUS Health, offering 24-hour access to a global network of over 80,000 independent specialised professionals who are there to support you and your family’s well-being
• Life assurance
• Flexible country-specific optional benefits, including childcare vouchers, bike purchase schemes, discounted gym memberships, subsidised travel passes, health assessments, among others

Visit our careers website to read more about the benefits of working at ICON: https://careers.iconplc.com/benefits

At ICON, inclusion & belonging are fundamental to our culture and values. We’re dedicated to providing an inclusive and accessible environment for all candidates. ICON is committed to providing a workplace free of discrimination and harassment. All qualified applicants will receive equal consideration for employment without regard to race, colour, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please let us know through the form below.

https://careers.iconplc.com/reasonable-accommodations

Interested in the role, but unsure if you meet all of the requirements? We would encourage you to apply regardless – there’s every chance you’re exactly what we’re looking for here at ICON whether it is for this or other roles.