We are seeking a highly motivated scientist with experience in recombinant protein production to join our structural biology research team and accelerate gene-to-structure workflows. The successful candidate will play a key role in the expression, purification, biophysical characterization of recombinant proteins and complexes to enable Cryo-EM and Crystallography projects. 

Protein Expression: Transfection of plasmids into mammalian cells and cell line maintenance, generation of baculovirus and expression of proteins in Sf9 cells, expression of proteins in bacterial systems. Good experience expressing proteins is very important for this position.

Protein Purification: Design, optimize, and execute protocols for the purification of recombinant proteins using commonly applied chromatography techniques (e.g., affinity, ion exchange, size exclusion).

Biophysical Characterization: Perform biophysical characterization of purified proteins, including but not limited to analytical SEC, Differential Scanning Fluorimetry (DSF), Thermal Stability Assays,

Data Analysis & Reporting: Maintain detailed records of experimental designs, data, and results. Analyze and interpret data for presentation to key stakeholders.

Team Collaboration: Work closely with structural biology team to determine protein constructs with optimal stability and functionality.

• Help the daily operations of the protein production team, maintaining a highly productive protein production laboratory, performing small- and large-scale expression and purification experiments, characterization of samples, and contributing to development of the lab.
• As a team member, develop and implement short and long-term strategies to enhance protein production capabilities.
• Help troubleshooting recombinant protein expression to maximize protein yield.

• BS/MS with minimal of 2-3 years of experience.
• Proven experience supporting drug discovery programs using structural biology and biochemistry is desirable.
• Good communication and interpersonal skills.
• Proven experience working with matrix teams.
• Self-driven, creative and entrepreneurial with ability to support multiple programs simultaneously.
• Cryo-EM and Crystallography experience is highly desirable but not required.
• Good understanding or experience with vectors and cloning strategies needed for protein expression in different cell systems.
• Ability to work independently (but under guidance) to deliver high quality purified protein samples and complexes for structural studies.
• Ability to efficiently and reproducibility follow established workflows.

What ICON can offer you:

Our success depends on the quality of our people. That’s why we’ve made it a priority to build a diverse culture that rewards high performance and nurtures talent.

In addition to your competitive salary, ICON offers a range of additional benefits. Our benefits are designed to be competitive within each country and are focused on well-being and work life balance opportunities for you and your family.

Our benefits examples include:

• Various annual leave entitlements
• A range of health insurance offerings to suit you and your family’s needs
• Competitive retirement planning offerings to maximise savings and plan with confidence for the years ahead
• Global Employee Assistance Programme, TELUS Health, offering 24-hour access to a global network of over 80,000 independent specialised professionals who are there to support you and your family’s well-being
• Life assurance
• Flexible country-specific optional benefits, including childcare vouchers, bike purchase schemes, discounted gym memberships, subsidised travel passes, health assessments, among others

Visit our careers website to read more about the benefits of working at ICON: https://careers.iconplc.com/benefits

At ICON, diversity, inclusion & belonging are fundamental to our culture and values. Our rich diversity makes us more innovative which helps us better serve our people, patients, customers, and our communities. We're proud of our diverse workforce and the work we’ve done to become a more inclusive organisation. We’re dedicated to providing an inclusive and accessible environment for all candidates. ICON is committed to providing a workplace free of discrimination and harassment. All qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please let us know through the form below.

https://careers.iconplc.com/reasonable-accommodations

Interested in the role, but unsure if you meet all of the requirements? We would encourage you to apply regardless – there’s every chance you’re exactly what we’re looking for here at ICON whether it is for this or other roles.